ISOLATION OF THYROXIN
نویسندگان
چکیده
منابع مشابه
Radiochromatographic Identification of Thyroxin
Iodine administered orally as NaI131 associates with two electrophoretically identifiable serum proteins (1-4). It appears first with the albumin fraction where it is associated with the slower moving component. It is later found in a zone of low protein concentration just ahead of alpha-2 globulin. This behavior was observed in the serum from both euthyroid and hyperthyroid subjects. However, ...
متن کاملComparative Effects of Thyroxin Analogues
DRIED THYROID SUBSTANCE or the pure natural hormoue s, L-thyroxin and L-triiodothyronine, effect a reduction in the serum total cholesterol of euthyroid individuals when administered in sufficient allmount.1-3 Their general clinical use to reduce elevated serum cholesterol levels in the hope of favorably influencing the course of atherosclerosis has been limited by two factors. When given in mo...
متن کاملDependence of the thyroxin/thyroxin-binding globulin (TBG) ratio and the free thyroxin index on TBG concentrations.
We studied the dependence of the free thyroxin (T4) index and the ratio of T4 to thyroxin-binding globulin (TBG) on TBG concentrations, using sera from cases of congenital TBG deficiency and congenital TBG excess. Two such sera with similar concentrations of albumin, transthyretin, and free T4 were mixed to provide test samples with TBG concentrations covering the range of clinical interest wit...
متن کاملEffect of anti-thyroxin autoantibodies on radioimmunoassay of free thyroxin in serum.
Serum thyroxin was nearly or completely undetectable by radioimmunoassay in an elderly patient with Graves' disease being treated with methimazole. Abnormal binding of thyroxin to antibodies of the IgG variety was shown, the association constant of the complex being 8.0 x 10(8) L/mol and the binding capacity 6.3 nmol/g of IgG. The effect of the antibody on results of radioimmunoassay of free th...
متن کاملAn evaluation of a fluorescence polarization immunoassay of thyroxin and thyroxin-uptake.
We evaluated the fluorescence polarization immunoassay for total thyroxin (T4) and thyroxin-uptake (T-U) in the Abbott "TDx" Analyzer. Between-assay precision was good when we did once-fortnightly calibration and assayed samples in singleton. Measured T4 concentration was decreased in hemolyzed samples with obvious red coloration and undetectable in severely hemolyzed samples. The T-U assay was...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1927
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)84373-3